Long-term effects of a ketogenic diet in obese patients
In a article in 2004 in the journal Experimental and Clinical Pathology. Hussein et al researched the effect of a ketogenic diet on obesity
They put patients on a 24-week ketogenic diet (consisting of 30 g carbohydrate, 1 g/kg body weight protein, 20% saturated fat, and 80% polyunsaturated and monounsaturated fat).
Patients were 83 obese patients with a BMI over 35 kg/ m2
The body weight, body mass index, total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, triglycerides, fasting blood sugar, urea and creatinine levels were determined before and after the administration of the ketogenic diet. Changes in these parameters were monitored after eight, 16 and 24 weeks of treatment.
1) The weight and body mass index of the patients decreased significantly (P<0.0001).
2) The level of total cholesterol decreased from week 1 to week 24.
3) HDL cholesterol levels significantly increased, whereas LDL cholesterol levels significantly decreased after treatment.
4) The level of triglycerides decreased significantly following 24 weeks of treatment.
5) The level of blood glucose significantly decreased.
The present study shows the beneficial effects of a long-term ketogenic diet. It significantly reduced the body weight and body mass index of the patients. Furthermore, it decreased the level of triglycerides, LDL cholesterol and blood glucose, and increased the level of HDL cholesterol. The present study also confirms that it is safe to use a ketogenic diet for a longer period of time than previously demonstrated.