Alzheimers obesity and insulin resistance

Alzheimers disease is linked to obesity, insulin resistance and obesity.

Can Alzheimer’s Be Cured

High insulin and high glucose are two of the most important risk factors for Alzheimer’s disease.

In prediabetes and  obesity the blood glucose levels are always higher than normal and that leads to high levels of insulin, that is called insulin resistance. (Lab. tests reveal high fasting Insulin and high HbA1c).

How then can insulin resistance contributing to Alzheimer’s disease?

1.Insulin signaling is one of the most important signals for the support of neuron survival. Insulin binds to the insulin receptor and triggers signaling that supports neuronal survival; this survival signal is blunted by chronically high insulin levels.

2.Insulin is being break down by IDE (Insulin degrading enzyme) But IDE also     degrades amyloid-beta, and if IDE is tied up degrading insulin, it isn’t degrading amyloid-beta. Amyloid-beta levels therefore increase, contributing to Alzheimer’s disease.

3.  Excess glucose is combining with proteins.  These hitchhiking glucose molecules undergo biochemical reactions to produce advanced glycationend products, or AGE. These AGE molecules damage anything they bump into, such as DNA and your cell membranes and creates chronic inflammation that is one of the key factors for the development of Alzheimer’s disease.

Source: Bredesen, Dale. The End of Alzheimer’s . Ebury Publishing. Kindle Edition.

No wonder that in the literature, one of the only chances that patients has against the brain fog of Alzheimers, is to revert their insulin resistance.

Also no wonder that the following article that appeared in the Journal of America Meidal Association, that was published January 2020 pointed out that medical research is busy to put glucose in the centre of Alzheimers research.
January 8, 2020

In Alzheimer Research, Glucose Metabolism Moves to Center Stage

JAMA. Published online January 8, 2020. doi:10.1001/jama.2019.20939

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